On July 7, 2023, NMPA released a new cosmetics supplementary testing method, BJH 202301 Determination of Tacrolimus and Pimecrolimus in Cosmetics, for the determination of the following two prohibited ingredients.
No. | Ingredient Name (CAS No.) | Detection Limit (ng) | Lower Quantitative Limit (ng) | Detection Concentration (mg/kg) | Minimum Quantitative Concentration (mg/kg) |
1 | Tacrolimus (104987-11-3) | 0.0004 | 0.001 | 0.01 | 0.025 |
2 | Pimecrolimus (137071-32-0) | 0.0004 | 0.001 | 0.01 | 0.025 |
These two ingredients are mainly used in the medical field but not allowed to be used in cosmetics. The new method is applicable for the determination of these two ingredients in cream, emulsion, and liquid (water, oil) cosmetics.
Original regulatory document
