On February 23, 2023, China National Institutes for Food and Drug Control (NIFDC) opened a public consultation on six technical guidelines for in vitro testing, determination for sun protection factor (SPF) and waterproof performance, as well as acute inhalation toxicity testing. This Guidelines is one of the six technical guidelines.

The method in this Guidelines is applicable to the acute inhalation toxicity test research of cosmetic ingredients that may have inhalation exposure risks. It does not apply to certain special ingredients, such as insoluble equiaxed or fibrous materials, and nanomaterials.

The test results can serve as the basis for acute inhalation toxicity assessment, and the determination of the dosage of subchronic toxicity tests and other toxicological tests.

The main contents of the Guidelines include the overview, basic principles, basic content (such as test substances, experimental animals, exposure methods, test methods and doses, observation time and indicators), result analysis and evaluation, references, terminology explanations, as well as an appendix. The appendix introduces a specific test method that can be referred to.