NIFDC opened three testing methods for cosmetic ingredients for public consultation on July 12, 2023, including Reactive Oxygen Species (ROS) Assay for Photoreactivity in Cosmetics. The details of this testing method are shown in the following table.
No. | Method Name | Testing Object | Testing Method | Applicable Scope | Drafting Purpose |
1 | Reactive Oxygen Species (ROS) Assay for Photoreactivity in Cosmetics (Draft for Comments) | Chemical ingredients for cosmetics | Reactive oxygen species (ROS) assay for photoreactivity | This method is applicable to the evaluation of potential phototoxicity of chemical ingredients used in cosmetics. | In 2016, the In-vitro 3T3 Neutral Red Uptake (NRU) Phototoxicity Test Method for Chemicals Used in Cosmeticswas included in STSC 2015 as a supplementary testing method. While this method can accurately identify most photostimulant chemicals, its ability to identify chemical substances in the photoallergen group is limited.
To address this, the Reactive Oxygen Species (ROS) Assay for Photoreactivity in Cosmetics was developed to predict the potential phototoxicity of chemical ingredients, complementing the existing phototoxicity testing method. With the in vitro ROS photoreactivity test method, the phototoxicity integration strategy can be enhanced and the in vitro alternative method system for cosmetics in China can be further improved. |
Original regulatory document
