On March 20, 2024, China National Institutes for Food and Drug Control (NIFDC) published the Technical Guidelines for Application of Threshold of Toxicological Concern (TTC) Method (the TTC Technical Guidelines) and the Technical Guidelines for Application of Read-across (the Read Across Technical Guidelines) for cosmetic safety assessment.
The TTC Technical Guidelines consists of six sections and three appendices, offering detailed instructions on employing TTC method for cosmetic safety assessment. Its content is as follows:
Overview
Scope of Application
Terms and Definitions
Substance Classification
Assessment Procedures
Mixture
Appendix 1 Flowchart of Safety Assessment on Cosmetics Applying TTC
Appendix 2 Example of Application of TTC Method in Safety Assessment of Cosmetic Ingredients (Chemicals)
Appendix 3 Example of Application of TTC Method in Safety Assessment of Cosmetic Ingredients (Plant Extracts)
Original regulatory document
