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On September 26, 2025, China's National Medical Products Administration (NMPA) issued a draft Announcement on Matters Concerning Toothpaste Notification Management for public consultation. Subsequently, on December 23, 2025, the finalized announcement was issued, easing the regulatory burden on the industry by allowing evidence of a history of safe use to substitute for toxicological testing requirements for existing toothpaste products.
Toothpaste is currently regulated by reference to general cosmetics. Under NMPA Announcement No. 124 of 2023, companies with existing products were permitted to complete a simplified notification during the transition period. However, they must still supplement a full notification dossier by December 1, 2025. The new announcement aims to further streamline this process for products with an established safety record.
