This document offers guidance to safety assessors evaluating the safety of these botanical raw materials in cosmetic products, considering the preparation of the botanical, concentration of use, possibility of harmful substances in the plant, traditional or non-traditional botanical ingredients.
Table of Content:
1. Introduction
2. Scope
3. Basis
4. Botanical raw material characterization
5. Exposure assessment
6. Toxicology testing
7. Risk assessment approaches
a. History of safe use
b. The comparative approach
c. TTC approaches for safety assessment
d. Local tolerance assessment
8. Making a decision
9. References
Appendix 1: Decision chart for safety assessment of botanical raw materials
Appendix 2: Glossary
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