JSQI 2021 is structured into three main parts: General Rules, General Testing Methods, and Individual Ingredient Specifications.

• General Rules: Contains 28 foundational provisions that define the standard's scope and application. It covers essential terminology, general testing principles, and the criteria used to determine the quality and acceptability of quasi-drug ingredients.

• General Testing Methods: Includes a comprehensive set of analytical procedures and foundational guidelines for testing quasi-drug ingredients. It contains around 78 specific test methods, such as the Residual Acrylic Monomer Test Method, Acrylonitrile Test Method, and Amine Value Determination Method. The section also sets out standardized requirements for the use of reagents, reference standards, standard solutions, and measuring instruments—ensuring consistency, reliability, and regulatory compliance in all testing processes.

• Ingredient Specifications: Lists 2,647 ingredients, each described with some or all of the following information (not every ingredient contains all items):

  1. Japanese name (official ingredient name)

  2. English name (chemical name)

  3. Japanese alias

  4. English alias

  5. Structural or rational formula

  6. Molecular formula and molecular weight

  7. Origin, the regulations of ingredients’ content and label

  8. Characteristics

  9. Identification tests

  10. Characteristic values

  11. Purity tests

  12. Loss on drying, ignition loss, and moisture

  13. Ignition residue or evaporation residue

  14. Special tests

  15. Quantitative methods

  16. Others