China NIFDC Consults on Seven Testing Methods for Cosmetic Ingredients, Toothpaste, and Toxicological Test

1

Determination of Phenacetin in Cosmetics

- This method stipulates the determination of phenacetin content in cosmetics by high-performance liquid chromatography-mass spectrometry (HPLC-MS). It is applicable for determining this ingredient in various cosmetic forms, including creams, emulsions, liquids, gels, and powders.

- Phenacetin was included into the Inventory of Prohibited Ingredients for Cosmetics by the National Medical Products Administration (NMPA) in 2021.

2

Determination of Glucuronic Acid and Other 13* Kinds of Components in Cosmetics

- This method specifies the determination of 14 ingredients in cosmetics by high-performance liquid chromatography (HPLC). It is applicable for determining these ingredients in various cosmetic forms, such as liquids, gels, creams, and emulsions.

- The 14 ingredients involved in this method include glucuronic acid, tartaric acid, glycolic acid, malic acid, lactic acid, citric acid, 2-hydroxybutyric acid, methyl lactate, mandelic acid, ethyl lactate, butyl lactate, benzilic acid, triethyl citrate, and hydroxycaprylic acid.

3

Determination of Gluconic Acid and Other Two* Kinds of Components in Cosmetics

- This method details the determination of three ingredients in cosmetics by HPLC. It is applicable for determining these ingredients in various cosmetic forms, including liquids, gels, creams, and emulsions.

- The three ingredients involved in this method are sodium gluconate, sodium lactobionate, and gluconolactone.

4

Determination of Hydroxycapric Acid in Cosmetics

- This method stipulates the determination of hydroxycapric acid content in cosmetics by HPLC. It is applicable for determining this ingredient in various cosmetic forms, including liquids, gels, creams, and emulsions.

5

Determination of Asbestos in Cosmetics

- This method describes the procedures for determining asbestos using a polarizing microscope, a scanning electron microscopy-energy dispersive spectrometer, and an X-ray diffractometer. It is applicable for the detection of asbestos in cosmetic ingredients and cosmetic products in various forms, such as powders, creams, and emulsions.

- Asbestos is a known carcinogen, and is prohibited for use in cosmetics. There is a potential risk of asbestos contamination in cosmetics through the presence of talc.

6

Determination of Soluble/Free Fluoride in Toothpastes

- This method explains the procedures for determining the content of soluble and free fluoride in toothpastes using the fluoride ion-selective electrode, and the ion chromatography.

7

The ARE-Nrf2 Luciferase LuSens Test

- This method outlines the basic principles, requirements, and procedures of the ARE-Nrf2 luciferase LuSens test. It is applicable for evaluating the potential sensitization of cosmetic ingredients.

Notes:

* The number mentioned here has been revised by ChemLinked after a thorough ingredient count in the method.