On 25 May, China Food and Drug Administration released test methods for a batch of substances prohibited and restricted in cosmetic products, aiming to further standardize requirements for cosmetics testing and enhance the safety and quality of cosmetics.
To be specific, test methods are available for the following substances:
Test Method 1. High Performance Liquid Chromatography (HPLC)
EN Name | CN Name | CAS | Property |
Diethyl maleate | 马来酸二乙酯 | 141-05-9 | Prohibited |
ACID VIOLET 43 | 酸性紫43 (CI 60730) | 4430-18-6 | Colorant |
Basic Violet 14 | 碱性紫14 (CI 42510) | 632-99-5 | Colorant |
Acid Orange 3 | 酸性橙3 (CI 10385) | 6373-74-6 | Colorant |
Basic yellow 87 | 碱性黄87 | 116844-55-4 | Colorant |
Basic Blue 26 | 碱性蓝26 (CI 44045) | 2580-56-5 | Colorant |
Basic red 51 | 碱性红51 | 12270-25-6 | Colorant |
Basic orange 31 | 碱性橙31 | 97404-02-9 | Colorant |
FOOD RED 9 | 食品红9 (CI 16185) | 915-67-3 | Colorant |
FOOD RED 7 | 食品红7 (CI 16255) | 1390-65-4 | Colorant |
FOOD RED 17 | 食品红17 (CI 16035) | 25956-17-6 | Colorant |
FOOD RED 1 | 食品红1 (CI 14700) | 4548-53-2 | Colorant |
ACID RED 87 | 酸性红87 (CI 45380) | 548-26-5 | Colorant |
ACID ORANGE 7 | 酸性橙7 (CI 15510) | 633-96-5 | Colorant |
SOLVENT GREEN 7 | 溶剂绿7 (CI 59040) | 6358-69-6 | Colorant |
ORANGE I | 橙黄 I | 523-44-4 | Colorant |
FOOD YELLOW 3 | 食品黄3 (CI 15985) | 2783-94-0 | Colorant |
ACID YELLOW 121 | 酸性黄1 (CI 10316) | 846-70-8 | Colorant |
Aminocaproic Acid | 氨基己酸 | 60-32-2 | |
Chlorphenesin | 氯苯甘醚 | 104-29-0 | Preservative |
Tretinoin | 维甲酸 | 302-79-4 | Prohibited |
Isotretinoin | 异维甲酸 | 4759-48-2 | |
Sorbicacid | 山梨酸 | 110-44-1 | |
Dehydroacetic Acid | 脱氢乙酸 | 520-45-6 | |
Salicylic acid | 水杨酸 | 69-72-7 | Restricted |
Zinc pyrithione | 吡硫翁锌 | Restricted/Preservative | |
Ketoconazole | 酮康唑 | Prohibited | |
Climbazole | 氯咪巴唑 | 38083-17-9 | Preservative |
Piroctone olamine | 吡罗克酮乙醇胺盐 | 68890-66-4 | Preservative |
Test Method 2. Using Headspace Gas Chromatography Flame Ionization Detector (HS-GC-FID)
EN Name | CN Name | CAS | Property |
Ethylene oxide | 环氧乙烷 | 75-21-8 | Prohibited |
Methyloxirane | 甲基环氧乙烷 | 75-56-9 | Prohibited |
Test Method 3. Liquid Chromatographic Tandem Mass Spectrometry (LC/MS/MS)
EN Name | CN Name | CAS | Property |
Enoxacin | 依诺沙星 | 74011-58-8 | Prohibited |
Fleroxacin | 氟罗沙星 | 79660-72-3 | Prohibited |
Ofloxacin | 氧氟沙星 | 82419-36-1 | Prohibited |
norfloxacin | 诺氟沙星 | 70458-96-7 | Prohibited |
Pefloxacin | 培氟沙星 | 70458-92-3 | Prohibited |
Ciprofloxacin | 环丙沙星 | 85721-33-1 | Prohibited |
Enrofloxacin | 恩诺沙星 | 93106-60-6 | Prohibited |
Sarafloxacin | 沙拉沙星 | 98105-99-8 | Prohibited |
Difloxacin | 双氟沙星 | 98106-17-3 | Prohibited |
Moxifloxacin | 莫西沙星 | 151096-09-2 | Prohibited |
Griseofulvin | 灰黄霉素 | 126-07-8 | Prohibited |
ketoconazole | 酮康唑 | 65277-42-1 | Prohibited |
clotrimazole crystalline | 克霉唑 | 23593-75-1 | Prohibited |
Econazole | 益康唑 | 27220-47-9 | Prohibited |
Miconazole | 咪康唑 | 22916-47-8 | Prohibited |
Fluconazole | 氟康唑 | 86386-73-4 | Prohibited |
Bifonazole | 联苯苄唑 | 60628-96-8 | Prohibited |
Ciclopirox olamine | 环吡酮胺 | 41621-49-2 | Prohibited |
Naftifine | 萘替芬 | 65472-88-0 | Prohibited |
Test Method 4. Gas Chromatography
EN Name | CN Name | CAS | Property |
α-Chlorotoluene | α-氯甲苯 | 100-44-7 | Prohibited |
Di-ethylene glycol | 二甘醇 | 111-46-6 |
In the Cosmetic Ingredient: 1,2-Propanediol |
Test Method 5. Iron Chromatography
EN Name | CN Name | CAS | Property |
Ethanolamine | 乙醇胺 | 141-43-5 | Prohibited |
Diethanolamine | 二乙醇胺 | 111-42-2 | |
Triethanolamine | 三乙醇胺 | 102-71-6 | |
Dimethylamine | 二甲胺 | 124-40-3 | |
Diethylamine | 二乙胺 | 109-89-7 |
Prohibited and restricted substances are included in the Hygienic Standards for Cosmetics 2007, which is being revised by CFDA and renamed as “Technical Safety Standard for Cosmetics”. Though the body text has been released for public comments last Dec (see Chemlinked news on 7 Dec 2012), its three annexes shown as follows are pending:
- Annex I: Technical requirements for cosmetic ingredients
- Annex II: Requirements for prohibited and restricted substances in cosmetics, including prohibited and restricted substances in cosmetics
- Annex III: Test methods (physic-chemical/ microbiological/toxicological/human safety/efficacy)