EU SCCS Issues Final Opinion on Benzophenone-1

In November 2024, EU Scientific Committee on Consumer Safety (SCCS) published a preliminary opinion on the use of Benzophenone-1 (CAS No. 131-56-6) in cosmetics. Considering the comments received, SCCS released its final opinion on April 1, 2025.¹

Benzophenone-1, listed in CosIng as a "light stabilizer" and "UV absorber", is used in various rinse-off and leave-on cosmetics to protect formulations from UV damage by absorbing and dispersing UV radiation. Responding to concerns over its potential endocrine disrupting properties, the European Commission initiated a call for data on Benzophenone-1 in 2021. Based on stakeholder submissions, SCCS conducted a safety assessment and developed this opinion.

In view of the available data and concerns related to genotoxicity and potential endocrine disrupting properties, SCCS concludes that Benzophenone-1 is not safe for use as a light stabilizer in cosmetics for the following reasons:

1. The available data indicates that Benzophenone-1 has genotoxic potential;

2. The evidence assessed by SCCS shows that Benzophenone-1 is an endocrine-active substance, demonstrated by clear estrogenic activity and weak anti-androgenic activity both in vitro and in vivo, as well as potential activity against thyroid modality in vitro.

Additionally, SCCS pointed out that the 2023 OECD TG 422 study on endocrine disrupting effects was not considered in the current safety assessment, due to the remaining concerns regarding the genotoxicity of Benzophenone-1. The committee will review the evidence supporting the safe use of Benzophenone-1 in cosmetics once a new mandate is received.

Further Reading

• EU SCCS Drafts Opinion on the UV Filter DHHB

• EU Updates Borderline Manual with Classification Guidance for Products in Vials and Ampoules

• EU Proposes Updates to the Glossary of Common Ingredient Names