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China Opens Testing Method of Anti-infective Agents in Cosmetics to Public Consultation

On Sep 14, China released a cosmetic testing method standardizing new requirements to test for anti-infective agents in cosmetic products. The draft is for public consultation until Sep 28, 2018, any advice or suggestions can be submitted through hzpbwh@nifdc.org.cn...

Takehome:

On Sep 14, China released a cosmetic testing method standardizing new requirements to test for anti-infective agents in cosmetic products. The draft is for public consultation until Sep 28, 2018, any advice or suggestions can be submitted through hzpbwh@nifdc.org.cn.

"Testing Method of Anti-infective Agents in Cosmetics" is used to screen for the presence of 36 kinds of anti-infective agents in cosmetic product types such as liquid water-based, cream, lotion, etc. and determine the quality and quantity by High Performance Liquid Chromatography-Tandem Mass Spectrometry (HPLC-MS/MS).

Anti-infective agents such as tetracyclines, quinolones, sulfonamides, lincosamides, nitrofurans are natural or synthetic drugs which have antibacterial and anti-inflammatory effects. Such kinds of drugs are under prescription drug management. Long-term use of anti-acne cosmetics that include illegally added anti-infective agents will irritate the skin, cause contact dermatitis and increases the potential for development of resistance amongst pathogens. China Safety and Technical Standards for Cosmetics and EU Cosmetics Directive (Directive 76/768/EEC) stipulate that anti-infective agents are prohibited ingredients used in cosmetics.

The 36 anti-infective agents are as follows:

36 kinds of anti-infective agents

Ingredients

CAS Number

Metronidazole

443-48-1

Sulfapyridine

144-83-2

Sulfamerazine

127-79-7

Sulfamethizole

144-82-1

Sulfamethoxypyridazine

80-35-3

Sulfaclorazina

80-32-0

Sulfamethoxazole

723-46-6

Enoxacin

74011-58-8

Sarafloxacin

98105-99-8

Pefloxacin

70458-92-3

Ofloxacin

82419-36-1

Fleroxacin

79660-72-3

Difloxacin

98106-17-3

Moxifloxacin

151096-09-2

Norfloxacin

70458-96-7

Ciprofloxacin

85721-33-1

Enrofloxacin

93106-60-6

Furaltadone

139-91-3

Lincomycin

154-21-2

Clindamycin

18323-44-9

Clindamycin phosphate

24729-96-2

Tetracycline

60-54-8

Doxycycline

564-25-0

Minocycline

10118-90-8

Oxytetracyclin

79-57-2

Aureomycin

57-62-5

Azithromycin

83905-01-5

Clarithromycin

81103-11-9

Roxithromycin

80214-83-1

Chloramphenicol

56-75-7

Spironolactone

52-01-7

Griseofulvin

126-07-8

Clotrimazole

23593-75-1

Ketoconazole

65277-42-1

Fluconazole

86386-73-4

Bifonazole

60628-96-8

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