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China Opens Testing Method of Anti-infective Agents in Cosmetics to Public Consultation

  •   18 Sep 2018
  •    Hedy He
  •  433
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    Takehome:

    On Sep 14, China released a cosmetic testing method standardizing new requirements to test for anti-infective agents in cosmetic products. The draft is for public consultation until Sep 28, 2018, any advice or suggestions can be submitted through hzpbwh@nifdc.org.cn.

    "Testing Method of Anti-infective Agents in Cosmetics" is used to screen for the presence of 36 kinds of anti-infective agents in cosmetic product types such as liquid water-based, cream, lotion, etc. and determine the quality and quantity by High Performance Liquid Chromatography-Tandem Mass Spectrometry (HPLC-MS/MS).

    Anti-infective agents such as tetracyclines, quinolones, sulfonamides, lincosamides, nitrofurans are natural or synthetic drugs which have antibacterial and anti-inflammatory effects. Such kinds of drugs are under prescription drug management. Long-term use of anti-acne cosmetics that include illegally added anti-infective agents will irritate the skin, cause contact dermatitis and increases the potential for development of resistance amongst pathogens. China Safety and Technical Standards for Cosmetics and EU Cosmetics Directive (Directive 76/768/EEC) stipulate that anti-infective agents are prohibited ingredients used in cosmetics.

    The 36 anti-infective agents are as follows:

    36 kinds of anti-infective agents

    Ingredients

    CAS Number

    Metronidazole

    443-48-1

    Sulfapyridine

    144-83-2

    Sulfamerazine

    127-79-7

    Sulfamethizole

    144-82-1

    Sulfamethoxypyridazine

    80-35-3

    Sulfaclorazina

    80-32-0

    Sulfamethoxazole

    723-46-6

    Enoxacin

    74011-58-8

    Sarafloxacin

    98105-99-8

    Pefloxacin

    70458-92-3

    Ofloxacin

    82419-36-1

    Fleroxacin

    79660-72-3

    Difloxacin

    98106-17-3

    Moxifloxacin

    151096-09-2

    Norfloxacin

    70458-96-7

    Ciprofloxacin

    85721-33-1

    Enrofloxacin

    93106-60-6

    Furaltadone

    139-91-3

    Lincomycin

    154-21-2

    Clindamycin

    18323-44-9

    Clindamycin phosphate

    24729-96-2

    Tetracycline

    60-54-8

    Doxycycline

    564-25-0

    Minocycline

    10118-90-8

    Oxytetracyclin

    79-57-2

    Aureomycin

    57-62-5

    Azithromycin

    83905-01-5

    Clarithromycin

    81103-11-9

    Roxithromycin

    80214-83-1

    Chloramphenicol

    56-75-7

    Spironolactone

    52-01-7

    Griseofulvin

    126-07-8

    Clotrimazole

    23593-75-1

    Ketoconazole

    65277-42-1

    Fluconazole

    86386-73-4

    Bifonazole

    60628-96-8

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    ChemLinked Editor

    Tracking regulatory change news in Asia Pacific area and focusing on cosmetic ingredient requirements, registration/filing/notification procedures of China and South Korea.

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