EU Updates Cosmetic Ingredient Lists to Address Newly Classified CMR Substances

The EU will adopt new changes to cosmetic ingredient lists of the Cosmetics Regulation on September 1, 2025, including: 1) List of prohibited ingredients: 21 addition and 1 revision 2) List of restricted ingredients: 1 deletion

On May 13, 2025, EU published Commission Regulation (EU) 2025/877 in its Official Journal, finalizing amendments to the prohibited and restricted ingredient lists of Regulation (EC) No 1223/2009 (Cosmetics Regulation). These changes, initially notified to the WTO in June 2024, reflect new classifications of CMR substances (those identified as carcinogenic, mutagenic, or toxic for reproduction) under Commission Delegated Regulation (EU) 2024/197. While the regulation will come into force on June 2, 2025, the updated ingredient requirements will apply from September 1, 2025.¹

Detailed changes introduced by the Commission Regulation are presented below, with red text indicating updates to existing lists:

1. List of Prohibited Ingredients: 21 added, and 1 revised

Following the classification established in Commission Delegated Regulation (EU) 2024/197, EU adds 21 CMR substances to the prohibited ingredients list, which are not yet regulated in the Cosmetics Regulation. Additionally, EU updates the existing entry for "2-cyano-N-[(ethylamino)carbonyl]-2-(methoxyimino)acetamide", incorporating an additional chemical name and CAS number for better clarity and legal certainty.

Status	Ref No.	Chemical Name/INN	CAS No.	EC No.
Revision	1580	Cymoxanil (ISO) / 2-cyano-N-[(ethylamino)carbonyl]-2-(methoxyimino)acetamide [1] (2E)-2-cyano-N-[(ethylamino)carbonyl]-2-(methoxyimino)acetamide [2]	57966-95-7 [1] 166900-80-7 [2]	261-043-0 [1] - [2]
Addition	1731	Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide / Trimethylbenzoyl Diphenylphosphine Oxide (INCI)	75980-60-8	278-355-8
	1732	2,2',6,6'-tetrabromo-4,4'-isopropylidenediphenol / tetrabromobisphenol-A	79-94-7	201-236-9
	1733	Transfluthrin (ISO) / 2,3,5,6-tetrafluorobenzyl (1R,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate	118712-89-3	405-060-5
	1734	Clothianidin (ISO) / (E)-1-(2-chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine	210880-92-5	433-460-1
	1735	Benzyl(diethylamino)diphenylphosphonium 4-[1,1,1,3,3,3-hexafluoro-2-(4-hydroxyphenyl)propan-2-yl]phenolate	577705-90-9	479-100-5
	1736	Benzyltriphenylphosphonium, salt with 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis[phenol] (1:1)	75768-65-9	278-305-5
	1737	Reaction mass of 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol and benzyl(diethylamino)diphenylphosphonium 4-[1,1,1,3,3,3-hexafluoro-2-(4-hydroxyphenyl)propan-2-yl]phenolate (1:1)	/	/
	1738	Reaction mass of 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol and benzyltriphenylphosphonium, salt with 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol (1:1)	/	/
	1739	Dimethyl propylphosphonate	18755-43-6	242-555-3
	1740	Dibutyltin maleate	78-04-6	201-077-5
	1741	Dibutyltin oxide	818-08-6	212-449-1
	1742	Reaction mass of 1-(2,3-epoxypropoxy)-2,2-bis ((2,3-epoxypropoxy)methyl) butane and 1-(2,3-epoxypropoxy)-2-((2,3-epoxypropoxy)methyl)-2-hydroxymethyl butane	/	/
	1743	4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol / bisphenol AF	1478-61-1	216-036-7
	1744	Benfluralin (ISO) / N-butyl-N-ethyl-α,α,α-trifluoro-2,6-dinitro-p-toluidine	1861-40-1	217-465-2
	1745	N,N-dimethyl-p-toluidine	99-97-8	202-805-4
	1746	1,4-Benzenediamine, N,N'-mixed Ph and tolyl derivs.	68953-84-4	273-227-8
	1747	4-nitrosomorpholine	59-89-2	/
	1748	Difenoconazole (ISO) / 1-({2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl}methyl)-1H-1,2,4-triazole / 3-chloro-4-[(2RS,4RS;2RS,4SR)-4-methyl-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-2-yl]phenyl 4-chlorophenyl ether	119446-68-3	/
	1749	4-methylimidazole	822-36-6	212-497-3
	1750	3,3'-dimethylbiphenyl-4,4'-diyl diisocyanate	91-97-4	202-112-7
	1751	Foramsulfuron (ISO) / 2-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-4-formamido-N,N-dimethylbenzamide / 1-(4,6-dimethoxypyrimidin-2-yl)-3-(2-dimethylcarbamoyl-5-formamidophenylsulfonyl)urea	173159-57-4	/

2. List of Restricted Ingredients: 1 deleted

The substance "Trimethylbenzoyl Diphenylphosphine Oxide" (CAS No. 75980-60-8), which is presently listed under Entry 311 of the restricted ingredients list, has been newly classified as a reproductive toxicant under Commission Delegated Regulation (EU) 2024/197. Given its inclusion in the prohibited ingredients list, EU removes it from the list.

Ref. No.	Substance Identification				Restrictions			Labelling of Use Conditions and Warnings
Ref. No.	Chemical Name / INN	Name of Common Ingredients Glossary	CAS No.	EC No.	Product Type	Maximum Concentration	Others	Labelling of Use Conditions and Warnings
311	Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide	Trimethylbenzoyl diphenylphosphine oxide	75980-60-8	278-355-8	Artificial nail systems	5%	Professional use	- For professional use only - Avoid skin contact - Read directions for use carefully

EU Updates Cosmetic Ingredient Lists to Address Newly Classified CMR Substances

1. List of Prohibited Ingredients: 21 added, and 1 revised

2. List of Restricted Ingredients: 1 deleted

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