On January 25, 2025, Canada published Canada Gazette, Part I, Volume 159, Number 4: Government Notices, which includes a Significant New Activity (SNAc) Notice for trisiloxane (3-ethyl-1,1,1,3,5,5,5-heptamethyl-, CAS No. 17861-60-8). 1
Trisiloxane is not listed on Canada’s Domestic Substances List. The government suspects that its use in certain cosmetic applications may pose risks, particularly concerning reproductive, developmental, and oral toxicity. Consequently, companies intending to undertake a SNAc involving this substance must submit a Significant New Activity Notification (SNAN) at least 90 days in advance, providing detailed safety data.
Scope of SNAc
1. Scope of a SNAc
1) The use of trisiloxane in the manufacture of a cosmetic other than: