Freckle-removing and whitening cosmetics are products designed to reduce or slow down skin pigmentation and achieve skin whitening effects. These cosmetics often contain ingredients that are considered to have relatively high risks and are therefore subject to stringent regulations worldwide. To assist enterprises in selecting appropriate ingredients and ensuring product safety, several countries have established regulations regarding permitted whitening agents and their usage limits. This article is an overview of the current regulatory status of freckle-removing and whitening cosmetics, as well as their active ingredients, in major cosmetics markets worldwide.